Characterization of a Mycobacterium bovis BCG insertion sequence related to the IS21 family

The structure and distribution of a Mycobacterium bovis BCG insertion element of the IS21 family were investigated. Several IS21-like elements found in mycobacterial genomes were separated in four types, following their nucleic acid similarities. The M. bovis BCG IS21 element is highly similar to IS...

Full description

Saved in:
Bibliographic Details
Published inFEMS microbiology letters Vol. 178; no. 2; pp. 211 - 217
Main Authors Lefèvre, Philippe, Braibant, Martine, Content, Jean, Gilot, Philippe
Format Journal Article
LanguageEnglish
Published Elsevier B.V 15.09.1999
Subjects
Corynebacteria-Mycobacteria-Nocardia group
IstA
IstB
Mycobacterium africanum
Mycobacterium avium
Mycobacterium bovis
Mycobacterium tuberculosis
IstA
Corynebacteria-Mycobacteria-Nocardia group
IstB
Online AccessGet full text

Cover

More Information
Summary:The structure and distribution of a Mycobacterium bovis BCG insertion element of the IS21 family were investigated. Several IS21-like elements found in mycobacterial genomes were separated in four types, following their nucleic acid similarities. The M. bovis BCG IS21 element is highly similar to IS1533 (class I), 70% similar to IS1534 (class II), 52% similar to IS1532 (class III) of Mycobacterium tuberculosis, and 54% similar to both an Mycobacterium avium serovar 2 and an M. avium silvaticum IS (class IV). The M. bovis BCG IS21 element of the class I appears to be present in a single copy in the genome of M. bovis BCG, M. bovis, M. tuberculosis and Mycobacterium africanum and to be absent from all other tested species of the Corynebacteria-Mycobacteria-Nocardia group.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0378-1097
1574-6968
DOI:10.1016/S0378-1097(99)00359-6