SOLID-PHASE SYNTHESIS OF POLYMER-BOUND β-KETOESTERS AND THEIR APPLICATION IN THE SYNTHESIS OF STRUCTURALLY DIVERSE PYRAZOLONES

An efficient solid-phase synthesis of different polymer-bound β-ketoesters 7 is described using readily available acid chlorides 1 and haloalkanes 6 as building blocks. The corresponding pyrazolones 9 and 10 were obtained by mild acid catalyzed reaction with phenylhydrazine or by treatment with hydr...

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 7; no. 10; pp. 1303 - 1306
Main Authors Tietze, Lutz F, Steinmetz, Adrian, Balkenhohl, Friedhelm
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 20.05.1997
Elsevier
Subjects
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings
Organic chemistry
Preparations and properties
Five membered ring
Ketoester
Solid phase
Chemical synthesis
Nitrogen heterocycle
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Summary:An efficient solid-phase synthesis of different polymer-bound β-ketoesters 7 is described using readily available acid chlorides 1 and haloalkanes 6 as building blocks. The corresponding pyrazolones 9 and 10 were obtained by mild acid catalyzed reaction with phenylhydrazine or by treatment with hydrazine under cyclisation and cleavage from the resin in high purity and good yield. © 1997 Elsevier Science Ltd.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(97)00209-6