Biospecific haemosorbents based on proteinase inhibitor: III. Biospecific antiproteinase haemosorbent ‘Ovosorb’ in complex therapy of acute destructive pancreatitis

• Published in: Biomaterials Vol. 15; no. 5; pp. 334 - 336
• Main Authors: Kirkovsky, Valerij V., Antiperovich, Oleg F., Valueva, Tatiana A., Moin, Victor M., Lobacheva, Galina A., Berezkina, Olga G.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 1994; Elsevier Science
• Subjects: Acute Disease; acute pancreatitis; antiproteinase haemosorbent; Biological and medical sciences; Haemosorbent; haemosorbtion; Hemoperfusion; Humans; Medical sciences; Multiple Organ Failure - therapy; Ovomucin - therapeutic use; ovomucoid; Pancreatitis - blood; Pancreatitis - therapy; Protease Inhibitors - metabolism; Protease Inhibitors - therapeutic use; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Technology. Biomaterials. Equipments. Material. Instrumentation; antiproteinase haemosorbent; Haemosorbent; haemosorbtion; ovomucoid; acute pancreatitis; Human; Hemadsorption; Enzyme; Apheresis; Acute; Pancreatitis; Enzyme inhibitor; Ovomucoid; Result; Specificity; Treatment; Digestive diseases; Hydrolases; Hydrogel; Adsorbent; Proteinases; Pancreatic disease
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/0142-9612(94)90244-5

Analysis was carried out of the results of complex therapy in 32 patients with acute destructive pancreatitis for which haemosorbtion on Ovosorb, a biospecific antiproteinase haemosorbent containing an immobilized ovomucoid, was used. The clinical efficiency of haemosorbtion was displayed as a decrease in gravity of endogenous intoxication and related functional and metabolic disturbances, as well as in a reduction of lethality from 24.7% to 6.2%.