Antibacterial and bioactivity of silver substituted hydroxyapatite/TiO2 nanotube composite coatings on titanium

• Published in: Applied surface science Vol. 314; pp. 348 - 357
• Main Authors: Yan, Yajing, Zhang, Xuejiao, Huang, Yong, Ding, Qiongqiong, Pang, Xiaofeng
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 30.09.2014; Elsevier
• Subjects: Antibacterial properties; Biocompatibility; Cell tests; Coating; Condensed matter: electronic structure, electrical, magnetic, and optical properties; Condensed matter: structure, mechanical and thermal properties; Cross-disciplinary physics: materials science; rheology; Electrochemical deposition; Exact sciences and technology; Hydroxyapatite; Nanostructure; Physics; Protective coatings; Silver; Silver ions; Surgical implants; TiO2 nanotubes; Titanium dioxide; Electrochemical deposition; TiO2 nanotubes; Hydroxyapatite; Antibacterial properties; Cell tests; Silver ions; Inorganic compounds; Transition element compounds; Nanotubes; Silver; Composite materials; Transition elements; Titanium; Electrodeposition; TiO; Titanium oxide
• ISSN: 0169-4332; 1873-5584
• DOI: 10.1016/j.apsusc.2014.07.027

•Silver-substituted hydroxyapatite coating was successfully deposited on anodic TiO2 nanotubes by electrochemical deposition.•The bond strength between the AgHAp coatings and the substrate was improved by anodization pretreatment.•The antibacterial capability of the HAp coatings were enhanced with Ag+ incorporation against E. coli.•The AgHAp coatings showed good biocompatibility and no adverse effect in cell culture tests. Hydroxyapatite doped with Ag+ ions (AgHAp) was synthesized via electrochemical deposition method on anodized titanium. The samples were characterized via X-ray diffraction, Fourier transform infrared spectrum analysis, X-Ray photoelectron spectroscopy and scanning electron microscopy to investigate the phase formation and microstructure of the samples. Highly ordered TiO2 nanotubes with a diameter of 100nm were successfully synthesized, and the AgHAp coating was deposited on the TiO2 nanotubes, which has a thickness of about 17.7±1.5μm. Moreover, silver was uniformly-distributed on the nanotubes. Bioactivity and electrochemical studies were performed for the AgHAp-coated TiO2 in a simulated body fluid, where significant good bioactivity and corrosion resistance were exhibited. The antibacterial and osteoblast cell adhesion tests in vitro revealed that the AgHAp coating with 2.03wt% silver had significant antibacterial and osteogenic properties. Thus, the AgHAp coating was regarded as a promising candidate for coating orthopedic implants.