Human c- fos proto-oncogene mapped to chromosome 14, band q24.3–q31 possibilities for oncogene activation by chromosomal rearrangements in human neoplasms

• Published in: Experimental cell research Vol. 169; no. 1; pp. 262 - 266
• Main Authors: Ekstrand, A.Jonas, Zech, Lore
• Format: Journal Article
• Language: English
• Published: Orlando, FL Elsevier Inc 1987; Elsevier
• Subjects: Animals; Biological and medical sciences; Biotechnology; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Cell Transformation, Neoplastic; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, Pair 14; Fundamental and applied biological sciences. Psychology; Gene therapy; Health. Pharmaceutical industry; Humans; Industrial applications and implications. Economical aspects; Lymphocyte Activation; Lymphocytes - cytology; Lymphocytes - immunology; Metaphase; Mice; Molecular and cellular biology; Neoplasms - genetics; Nucleic Acid Hybridization; Proto-Oncogenes; Genetic mapping; Human; Molecular hybridization; D14»-Chromosome; C-Onc gene; In situ; Gene rearrangement; Tumor; Tumorigenicity
• ISSN: 0014-4827; 1090-2422
• DOI: 10.1016/0014-4827(87)90244-8

The human c- fos proto-oncogene was mapped by in situ hybridization to chromosome 14, band q24.3–q31. As a probe we used 3H-labelled mouse c- fos RNA transcribed in vitro by SP6-RNA-polymerase. Of a total of 40 grains on chromosome 14, 19 (47.5%) were located within the 14q24.3-q31 region ( p ⪡ 0.001). Mechanisms for c- fos to gain transforming ability by a break in a critical part of the gene have recently been described. Thus there are several possibilities for chromosomal aberrations within the 14q24.3–q31 region to be responsible for c- fos deregulation and which may result in neoplastic growth. Such specific aberrations are found in a variety of human neoplasms.