Humoral immunity in oral contraceptive users: II. In Vitro Immunoglobulin Production

The worldwide acceptance of steroid-based oral contraception makes it imperative that the effect of these agents on the immune system is understood. Nevertheless, information regarding the effect of steroid-based oral contraception on humoral immunoregulation is limited. In this report the in vitro...

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Bibliographic Details
Published inContraception (Stoneham) Vol. 38; no. 5; pp. 573 - 578
Main Authors Bisset, Leslie R., Griffin, J.Frank T.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.11.1988
Elsevier Science
Subjects
Antibody Formation
Biological and medical sciences
Birth control
Contraceptives, Oral, Hormonal
Enzyme-Linked Immunosorbent Assay
Female
Gynecology. Andrology. Obstetrics
Hormonal contraception
Humans
Immunoglobulin G - biosynthesis
Immunoglobulin M - biosynthesis
Medical sciences
Population
Human
Cell culture
Immunoglobulins
Immune response
Acquired immunity
Oral administration
Female
Contraceptive
Contraception
Sex steroid hormone
In vitro
Hemic System
Contraceptive Agents
Contraceptive Agents, Progestin
Levonorgestrel
Contraceptive Agents, Estrogen
Biology
Hormones
Ethinyl Estradiol
Family Planning
Endocrine System
Oceania
New Zealand
Developed Countries
Hematological Effects
Contraceptive Methods
Developing Countries
Physiology
Oral Contraceptives
Immunoglobulin Alterations
Contraceptive Agents, Female
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Summary:The worldwide acceptance of steroid-based oral contraception makes it imperative that the effect of these agents on the immune system is understood. Nevertheless, information regarding the effect of steroid-based oral contraception on humoral immunoregulation is limited. In this report the in vitro production of IgG and IgM is measured following stimulation with either the T-dependent activator pokeweed mitogen (PWM) or the T-independent activator fixed/killed Staphylococcus aureus Cowan I (StaCw). No significant differences are observed between the in vitro IgG or IgM levels following stimulation with PWM or StaCw for females taking steroid-based oral contraceptives and females not taking steroid-based oral contraceptives. We conclude that humoral immunoregulation is unaltered in steroid-based oral contraceptive users.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0010-7824
1879-0518
DOI:10.1016/0010-7824(88)90161-8