Recent advances in CAR T-cell engineering using synthetic biology: Paving the way for next-generation cancer treatment

• Published in: Advances in protein chemistry and structural biology Vol. 140; pp. 91 - 156
• Main Authors: Dey, Sangita, Devender, Moodu, Rani, Swati, Pandey, Rajan Kumar
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 2024
• Subjects: Cancer; CAR T-Cell; Cell Engineering; Gene Editing; Humans; Immunotherapy, Adoptive - methods; Neoplasms - genetics; Neoplasms - immunology; Neoplasms - therapy; Receptors, Chimeric Antigen - genetics; Receptors, Chimeric Antigen - immunology; Synthetic Biology; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; Therapy; Treatment; Therapy; Synthetic biology; Treatment; CAR T-Cell; Cancer
• ISSN: 1876-1623; 1876-1631; 1876-1631
• DOI: 10.1016/bs.apcsb.2024.02.003

This book chapter highlights a comprehensive exploration of the transformative innovations in the field of cancer immunotherapy. CAR (Chimeric Antigen Receptor) T-cell therapy represents a groundbreaking approach to treat cancer by reprogramming a patient immune cells to recognize and destroy cancer cells. This chapter underscores the critical role of synthetic biology in enhancing the safety and effectiveness of CAR T-cell therapies. It begins by emphasizing the growing importance of personalized medicine in cancer treatment, emphasizing the shift from one-size-fits-all approaches to patient-specific solutions. Synthetic biology, a multidisciplinary field, has been instrumental in customizing CAR T-cell therapies, allowing for fine-tuned precision and minimizing unwanted side effects. The chapter highlights recent advances in gene editing, synthetic gene circuits, and molecular engineering, showcasing how these technologies are optimizing CAR T-cell function. In summary, this book chapter sheds light on the remarkable progress made in the development of CAR T-cell therapies using synthetic biology, providing hope for cancer patients and hinting at a future where highly personalized and effective cancer treatments are the norm.