Reactions of nitric oxide with amines in the presence of dioxygen

Nitric oxide (NO), a multifaceted bioregulatory agent and an environmental pollutant, can effectively convert aromatic amines to the corresponding triazenes under aerobic conditions, but not under anaerobic conditions. Nucleic acid bases and nucleosides are also deaminated via hydrolysis of the diaz...

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Bibliographic Details
Published inTetrahedron letters Vol. 36; no. 45; pp. 8239 - 8242
Main Authors Nagano, Tetsuo, Takizawa, Hiromasa, Hirobe, Masaaki
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 1995
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
CELLS
RELAXING FACTOR
RELEASE
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Summary:Nitric oxide (NO), a multifaceted bioregulatory agent and an environmental pollutant, can effectively convert aromatic amines to the corresponding triazenes under aerobic conditions, but not under anaerobic conditions. Nucleic acid bases and nucleosides are also deaminated via hydrolysis of the diazonium ion products with exposure to aerobic NO solution. A peroxynitrite radical or nitrogen dioxide is suggested to be the ultimate reactive species.
ISSN:0040-4039
1873-3581
DOI:10.1016/0040-4039(95)01715-T