Penicillamine-induced Myositis: Observations and unique features in two patients and review of the literature

Dermatomyositis developed during treatment with penicillamine in two patients with rheumatoid arthritis. Both were male without a history of penicillin allergy. Eosinophilia was present at the start of their illness, and HLA tissue typing showed the presence of HLA-DR2 in one patient. One patient wa...

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Bibliographic Details
Published inThe American journal of medicine Vol. 77; no. 4; pp. 719 - 722
Main Authors Halla, James T., Fallahi, Sohrab, Koopman, William J.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 1984
Subjects
Adult
Arthritis, Rheumatoid - drug therapy
Biopsy
Dermatomyositis - chemically induced
Dermatomyositis - immunology
Eosinophilia - chemically induced
Histocompatibility Antigens Class II - analysis
HLA-DR Antigens
Humans
Male
Middle Aged
Muscles - immunology
Penicillamine - adverse effects
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Summary:Dermatomyositis developed during treatment with penicillamine in two patients with rheumatoid arthritis. Both were male without a history of penicillin allergy. Eosinophilia was present at the start of their illness, and HLA tissue typing showed the presence of HLA-DR2 in one patient. One patient was retreated with penicillamine and remained asymptomatic after three years of therapy, and the other was able to take penicillamine in a reduced dosage.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
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ISSN:0002-9343
1555-7162
DOI:10.1016/0002-9343(84)90371-1