Audiological Management of Patients Receiving Aminoglycoside Antibiotics

Aminoglycoside antibiotics, commonly prescribed for adults and children to treat a wide range of bacterial infections, are potentially ototoxic, often causing irreversible damage to the auditory and vestibular systems. Ototoxic hearing loss usually begins at the higher frequencies and can progress t...

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Bibliographic Details
Published inThe Volta review Vol. 105; no. 3; pp. 229 - 250
Main Authors Konrad-Martin, Dawn, Wilmington, Debra J, Gordon, Jane S, Reavis, Kelly M, Fausti, Stephen A
Format Journal Article
LanguageEnglish
Published Washington Alexander Graham Bell Association for the Deaf and Hard of Hearing 01.12.2005
Alexander Graham Bell Association for the Deaf, Incorporated
Subjects
Adults
Antibiotics
At Risk Persons
Audiometry
Auditory Tests
Child development
Children
Communication Problems
Deafness
Diseases
Drug Therapy
Genetics
Hearing disorders
Hearing Impairments
Heredity
Infections
Language acquisition
Narcotics
Neonates
Patients
Pharmacology
Population Distribution
Speech
Toxicity
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Summary:Aminoglycoside antibiotics, commonly prescribed for adults and children to treat a wide range of bacterial infections, are potentially ototoxic, often causing irreversible damage to the auditory and vestibular systems. Ototoxic hearing loss usually begins at the higher frequencies and can progress to lower frequencies necessary for understanding speech. Individual susceptibility to aminoglycoside ototoxicity is determined by multiple physiologic and genetic factors. Children are especially vulnerable to ototoxic-induced damage, which can affect speech and language development even when limited to the high frequencies. Monitoring hearing loss during and after treatment by conventional and ultra-high frequency audiometry allows early detection of ototoxic hearing loss. Objective measures such as auditory brainstem responses (ABRs) and otoacoustic emissions (OAEs) can provide information about auditory function for individuals unable to provide reliable behavioral data, including young children. Early detection and subsequent alteration of treatment, as well as the potential future use of otoprotectants, may minimize or prevent ototoxic hearing loss.
ISSN:0042-8639
2162-5158