Suppressive effect of X-irradiated tumor cell presensitization on the induction of syngeneic tumor immunity: II. Opposite effects of intravenous administration of TNP-conjugated tumor cells on the development of antitumor and anti-TNP-self cytotoxic effector cells

• Published in: Cellular immunology Vol. 59; no. 1; pp. 181 - 186
• Main Authors: Fujiwara, Hiromi, Shearer, Gene M.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 15.03.1981
• Subjects: Animals; Antibodies, Neoplasm - immunology; Cytotoxicity, Immunologic; Female; Mice; Mice, Inbred C3H; Nitrobenzenes - immunology; Plasmacytoma - immunology; T-Lymphocytes - immunology; Trinitrobenzenes - immunology; X-Rays

A comparison was made of the effects of iv inoculation of trinitrophenyl (TNP)-conjugated syngeneic X5563 tumor cells on the development of anti-TNP-modified self (TNP-self) and anti-X5563 tumor-specific T-cell-mediated cytotoxic responses. Administration of syngeneic TNP-conjugated spleen cells or...