Laboratory-developed simulated moving bed for chiral drug separations: Design of the system and separation of Tramadol enantiomers

The design of a laboratory-developed simulated moving bed (SMB) is described. The main features of the system are outlined. The efficiency of the SMB to resolve chiral drugs is illustrated by the separation of Tramadol enantiomers at various feed concentrations. Advantages over preparative batch chr...

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Bibliographic Details
Published inJournal of Chromatography A Vol. 769; no. 1; pp. 49 - 57
Main Authors Cavoy, E., Deltent, M.-F., Lehoucq, S., Miggiano, D.
Format Journal Article Conference Proceeding
LanguageEnglish
Published Amsterdam Elsevier B.V 02.05.1997
Elsevier
Subjects
Analysis
Analytical chemistry
Biological and medical sciences
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
General pharmacology
Medical sciences
Other chromatographic methods
Pharmacology. Drug treatments
Tramadol
Simulated moving bed
Preparative chromatography
Tramadol
Enantiomer separation
Aminoalcohol
Separation
Phase composition
simulated moving bed
HPLC chromatography
Chiral stationary phase
Experimental study
Mobile phase
Analgesic
Ultraviolet detector
Optical resolution
Enantiomer
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Summary:The design of a laboratory-developed simulated moving bed (SMB) is described. The main features of the system are outlined. The efficiency of the SMB to resolve chiral drugs is illustrated by the separation of Tramadol enantiomers at various feed concentrations. Advantages over preparative batch chromatography in terms of solvent and chiral phase consumption are demonstrated.
ISSN:0021-9673
DOI:10.1016/S0021-9673(96)00964-8