Diagnostic Efficacy of 18F-FDG PET/CT in Detecting Bone Marrow Infiltration in Patients with Newly Diagnosed Diffuse Large B-Cell Lymphoma

• Published in: Biomedical and environmental sciences Vol. 36; no. 6; pp. 510 - 516
• Main Authors: GUO, Bo, QIN, Ran, GU, Zhen Yang, LI, Yan Fen, GAO, Lei, HUANG, Wen Rong
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.06.2023; Department of Hematology,The Second Medical Center&National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China%Department of Hematology,The Fifth Medical Center,Chinese PLA General Hospital,Beijing 100071,China%Department of Medical Engineering,Medical Supplies Center of PLA General Hospital,Beijing 100039,China
• Subjects: Bone marrow biopsy; Bone marrow infiltration; Diagnostic efficacy; Diffuse large B-cell lymphoma; Positron emission computed tomography (PET/CT); Bone marrow biopsy; Positron emission computed tomography (PET/CT); Bone marrow infiltration; Diagnostic efficacy; Diffuse large B-cell lymphoma; Positron emission computed tomography(PET/CT)
• ISSN: 0895-3988; 2214-0190
• DOI: 10.3967/bes2023.062

Diffuse large B-cell lymphoma (DLBCL) is often associated with bone marrow infiltration, and 2-deoxy-2-(18F) fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has potential diagnostic significance for bone marrow infiltration in DLBCL. A total of 102 patients diagnosed with DLBCL between September 2019 and August 2022 were included. Bone marrow biopsy and 18F-FDG PET/CT examinations were performed at the time of initial diagnosis. Kappa tests were used to evaluate the agreement of 18F-FDG PET/CT with the gold standard, and the imaging features of DLBCL bone marrow infiltration on PET/CT were described. The total detection rate of bone marrow infiltration was not significantly different between PET/CT and primary bone marrow biopsy (P = 0.302) or between the two bone marrow biopsies (P = 0.826). The sensitivity, specificity, and Youden index of PET/CT for the diagnosis of DLBCL bone marrow infiltration were 0.923 (95% CI, 0.759–0.979), 0.934 (95% CI, 0.855–0.972), and 0.857, respectively. 18F-FDG PET/CT has a comparable efficiency in the diagnosis of DLBCL bone marrow infiltration. PET/CT-guided bone marrow biopsy can reduce the misdiagnosis of DLBCL bone marrow infiltration.