Heart rate variability as an indicator of brain health in neurodegeneration

• Published in: Progress in brain research Vol. 294; pp. 75 - 96
• Main Authors: Kubra, Ghulam, Raza, Muhammad Liaquat
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 2025
• Subjects: Autonomic nervous system; Autonomic Nervous System - physiopathology; Brain - physiopathology; Brain health; Cognitive function; Heart Rate - physiology; Heart rate variability; Humans; Neurodegeneration; Neurodegenerative Diseases - physiopathology; Brain health; Cognitive function; Neurodegeneration; Autonomic nervous system; Heart rate variability
• ISSN: 0079-6123; 1875-7855; 1875-7855
• DOI: 10.1016/bs.pbr.2025.04.007

[Display omitted] Heart Rate Variability (HRV) has emerged as a promising indicator of brain health in neurodegenerative diseases. This chapter explores the intricate relationship between HRV and cognitive function, shedding light on its potential as a biomarker for neurological decline. We delve into the mechanisms underlying HRV and its connection to autonomic nervous system function, stress response, and memory processes. The chapter examines how HRV is affected in various neurodegenerative conditions and its associations with depression and cardiovascular health. We discuss the methods of monitoring HRV and factors influencing its measurements. The role of HRV in predicting agitation and its correlation with neuroimaging findings in neurodegenerative diseases are also explored. Finally, we consider strategies for improving HRV and their potential impact on brain health, offering insights into possible interventions for individuals at risk of or living with neurodegenerative disorders.