A lysis less ordinary: The bacterial Type 10 Secretion System

• Published in: Advances in microbial physiology Vol. 86; pp. 175 - 198
• Main Authors: Chowdhury, Mechna, Stansfeld, Phillip J., Sargent, Frank
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 2025
• Subjects: Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Bacterial Secretion Systems - genetics; Bacterial Secretion Systems - metabolism; Bacterial Secretion Systems - physiology; Bacteriolysis; Bacteriophages; Gram-Negative Bacteria - genetics; Gram-Negative Bacteria - metabolism; N-Acetylmuramoyl-L-alanine Amidase - genetics; N-Acetylmuramoyl-L-alanine Amidase - metabolism
• ISSN: 0065-2911; 2162-5468; 2162-5468
• DOI: 10.1016/bs.ampbs.2025.02.002

Bacteria have evolved several different biochemical pathways to either export proteins of all shapes and sizes out of the cell cytoplasm, or to secrete those proteins into the extracellular environment. Many bacterial protein secretion systems have evolutionary links to systems used by bacteriophage to move macromolecules across membranes. The Type 10 Secretion System (T10SS) was identified in gram-negative bacteria and comprises genes that bear striking sequence similarities to those found within phage lysis cassettes. The minimum components of a T10SS are an integral membrane holin-like protein together with a peptidoglycan hydrolase. Here, we review recent research in Serratia spp., Salmonella spp, Yersinia spp, and gram-positive Clostridioides spp., and consider the evidence for different T10SS mechanisms ranging from a controlled release of proteins into the environment, to stochastic altruistic lysis of specialised populations of cells.