In vivo growth-inhibition of S180 tumor by mixture of 5-Fu and low molecular λ-carrageenan from Chondrus ocellatus

• Published in: Pharmacological research Vol. 51; no. 2; pp. 153 - 157
• Main Authors: Zhou, Gefei, Xin, Hua, Sheng, Wenxu, Sun, Yueping, Li, Zhien, Xu, Zuhong
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.02.2005
• Subjects: 5-Fu; Animals; Antitumor; Carrageenan - administration & dosage; Carrageenan - isolation & purification; Chondrus - isolation & purification; Drug Therapy, Combination; Fluorouracil - administration & dosage; Growth Inhibitors - administration & dosage; Immunocompetence; Low molecular λ-carrageenan; Mice; Mice, Inbred ICR; Sarcoma 180 - drug therapy; Sarcoma 180 - pathology; Low molecular λ-carrageenan; Immunocompetence; Antitumor; 5-Fu
• ISSN: 1043-6618; 1096-1186
• DOI: 10.1016/j.phrs.2004.07.003

λ-carrageenan is a sulfated galactan isolated from some red algae and have been reported to have many kinds of biological activities. Chondrus ocellatus is an important economic alga in China and many other parts of the world. The sample was obtained after λ-carrageenan from the alga was degraded by microwave and its molecular weight is 9.3 kDa. In this study, tumor inhibiting activity of low molecular weight λ-carrageenan and its mixture with 5-Fu on mice transplanted with S180 tumor was investigated. Weight of immune organ, proliferation ratio of lymphocyte concentration of TNF-α and histopathology of spleen and tumor from the transplanted S180 tumor mice were also determined. Results indicated that the degraded λ-carrageenan could enhance antitumor activity of 5-Fu and improve immunocompetence damaged by 5-Fu.