Evaluation of the carcinogenic potential of pesticides. 3. Aliette

• Published in: Regulatory toxicology and pharmacology Vol. 14; no. 1; p. 3
• Main Authors: Quest, J A, Hamernik, K L, Engler, R, Burnam, W L, Fenner-Crisp, P A
• Format: Journal Article
• Language: English
• Published: Netherlands 01.08.1991
• Subjects: Adrenal Gland Neoplasms - chemically induced; Animals; Carcinogens - toxicity; Female; Fungicides, Industrial - toxicity; Male; Mice; Mutagenicity Tests; Mutagens - toxicity; Organophosphorus Compounds - toxicity; Rats; Structure-Activity Relationship; United States; United States Environmental Protection Agency; Urinary Bladder Neoplasms - chemically induced; United States
• ISSN: 0273-2300
• DOI: 10.1016/0273-2300(91)90047-Y

Aliette, a fungicide compound, was evaluated for carcinogenic potential by the Health Effects Division of the Office of Pesticide Programs using a consensus peer review process and EPA's guidelines for risk assessment. Aliette was categorized as a group C (possible human) carcinogen based upon evidence of an increased incidence of combined benign and malignant urinary bladder tumors in a single study involving male Charles River (CR) CD rats. The bladder tumors occurred only at the unusually high top dose level of aliette that was tested (40,000/30,000 ppm). The compound was not carcinogenic in female CR-CD rats in the same study, or in CD-1 mice of either sex in a second study. Monosodium phosphite, the main urinary metabolite of aliette, was also not carcinogenic in male or female CR-CD rats. Aliette was not demonstrated to be genotoxic. No structural analogues of aliette were identified. The mechanism of action for the production of bladder tumors was not identified; however, it did not appear to involve a genotoxic effect, a carcinogenic effect of metabolites, or the formation of renal stones. The data were not found to be sufficient to quantify human cancer risk from aliette.