Production of duodenal ulcers by exogenous gastrin: An experimental model

These experiments demonstrate that hog gastrin combined with gelatin gave a sustained release of gastrin which resulted in a prolonged increase in gastric acid production in dogs with a Heidenhain pouch. When gastrin was given to guinea pigs in this manner at a dosage of 35 gm. of antral mucosa per...

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Bibliographic Details
Published inThe American journal of surgery Vol. 113; no. 2; pp. 183 - 187
Main Authors Gobbel, W.G., Adkins, R.Benton
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.02.1967
Subjects
Animals
Dogs
Duodenal Ulcer - chemically induced
Duodenal Ulcer - pathology
Female
Gastric Juice
Gastric Mucosa - physiology
Gastrins - pharmacology
Gelatin - pharmacology
Guinea Pigs
Injections, Subcutaneous
Male
Swine
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Summary:These experiments demonstrate that hog gastrin combined with gelatin gave a sustained release of gastrin which resulted in a prolonged increase in gastric acid production in dogs with a Heidenhain pouch. When gastrin was given to guinea pigs in this manner at a dosage of 35 gm. of antral mucosa per kilogram of body weight every twelve hours, the incidence of duodenal ulcer was 74 per cent in thirty-five experimental animals within fourteen days.
ISSN:0002-9610
1879-1883
DOI:10.1016/0002-9610(67)90219-X