Mixed lymphocyte reactivity in spleen cells from F-9 tumor-bearing mice: II. Functional cross-reactivity between F-9 cells and testicular cells

Previous serological analysis has revealed cross-reactive antigens on F-9 cells and mouse germ cells. Therefore, we investigated whether suppressor activity in spleen cells from F-9 tumor-bearing mice can be restimulated in vitro by adding F-9 cells or testicular cells to mixed lymphocyte cultures....

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Bibliographic Details
Published inCellular immunology Vol. 62; no. 2; pp. 341 - 349
Main Authors Hurtenbach, Ursula, Bennett, Dorothea, Bluestone, Jeffrey A.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Inc 01.08.1981
Subjects
Animals
Cell Transformation, Neoplastic
Cross Reactions
Lymphocyte Activation
Lymphocyte Culture Test, Mixed
Male
Mice
Mice, Inbred A
Mice, Inbred BALB C
Mice, Inbred C57BL
Neoplasms, Experimental - immunology
Spleen - cytology
T-Lymphocytes, Regulatory - immunology
Teratoma - immunology
Testis - cytology
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Summary:Previous serological analysis has revealed cross-reactive antigens on F-9 cells and mouse germ cells. Therefore, we investigated whether suppressor activity in spleen cells from F-9 tumor-bearing mice can be restimulated in vitro by adding F-9 cells or testicular cells to mixed lymphocyte cultures. We found equal potentiation of suppressor T-cell activity with F-9 cells and with syngeneic testicular cells; as shown by sensitivity to anti-Lyt 2.2 plus complement treatment. Suppressor activity of spleen cells from other tumor systems tested was not enhanced. The data suggest that the same or cross-reactive antigens on F-9 teratocarcinoma cells and testicular cells may have similar regulatory functions.
ISSN:0008-8749
1090-2163
DOI:10.1016/0008-8749(81)90335-X