The effects of Calotropis procera on small ruminants : II. Effects of administration of the latex to sheep and goats

Acute toxicity of Calotropis procera was studied in Desert sheep and Nubian goats given single or multiple doses (6-0·001 ml per kg) of the latex of the plant by oral, intravenous, intraperitoneal or subcutaneous routes. Administration of the latex of C. procera by all routes caused deaths in both s...

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Bibliographic Details
Published inJournal of comparative pathology Vol. 89; no. 2; pp. 251 - 263
Main Authors Mahmoud, O.M., Adam, S.E.I., Tartour, G.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.1979
Subjects
Animals
Goats
Lipids - analysis
Male
Plant Extracts - poisoning
Plant Poisoning - blood
Plant Poisoning - pathology
Plant Poisoning - veterinary
Sheep
Sheep Diseases - blood
Sheep Diseases - etiology
Sheep Diseases - pathology
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Summary:Acute toxicity of Calotropis procera was studied in Desert sheep and Nubian goats given single or multiple doses (6-0·001 ml per kg) of the latex of the plant by oral, intravenous, intraperitoneal or subcutaneous routes. Administration of the latex of C. procera by all routes caused deaths in both species. The animals developed nervous signs, urination, tachycardia, dyspnoea and loss of condition. Severe pathological changes were seen in the liver, kidneys, heart, lungs, brain and intestines. These were correlated with changes in the concentration of total protein, ammonia, bilirubin, sodium, potassium, calcium and creatinine in the serum. The concentrations of total lipids in the liver, heart and kidneys were raised. The increase in RBC, PCV and Hb was probably due to haemoconcentration.
ISSN:0021-9975
1532-3129
DOI:10.1016/0021-9975(79)90064-1