Hepatic drug metabolism and gut microbiome

• Published in: Progress in molecular biology and translational science Vol. 191; no. 1; pp. 207 - 228
• Main Authors: Mehrotra, Tanshi, Maulik, Subir Kumar
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 2022
• Subjects: Drug metabolism pathways; Gut microbiota dysbiosis; Hepatic drug metabolism; Infectious diseases; Intestinal disorders; Intestinal microbiota; Keystone species; Keystone species associated with drug metabolism; Metabolic disorders; Keystone species; Hepatic drug metabolism; Keystone species associated with drug metabolism; Infectious diseases; Intestinal disorders; Intestinal microbiota; Drug metabolism pathways; Metabolic disorders; Gut microbiota dysbiosis
• ISSN: 1877-1173; 1878-0814; 1878-0814
• DOI: 10.1016/bs.pmbts.2022.07.005

This chapter focuses on intestinal microbiota and its effect on drug metabolism. Here, we discussed about different drugs which are metabolized either by some enzymes or gut microbiota and their mechanism. Nowadays, consuming drugs without a doctor's prescription is common. This chapter will make people aware about its negative consequences and how it is related to gut microbiota dysbiosis. Intestinal disorders like inflammatory bowel disease (IBD), colorectal cancer (CRC) and metabolic disorders such as obesity and type 2 diabetes mellitus (T2D) are found to be affected with gut microbiota dysbiosis. To address this issue, we discussed a variety of strategies such as fecal microbiota transplantation (FMT), probiotics and antibiotic stewardship programs which are commonly used to tackle this problem.