Total synthesis of 4( RS)-F 4t-isoprostane methyl ester

The first total synthesis of 4( RS)-F 4t-isoprostane methyl ester 1 is described using diacetone- d-glucose as starting material. This new isoprostane (neuroprostane) would be very useful in neurological studies as a potent lipid peroxidation index to obtain an integrated assessment of oxidative str...

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Bibliographic Details
Published inTetrahedron letters Vol. 41; no. 20; pp. 3859 - 3862
Main Authors Durand, Thierry, Guy, Alexandre, Vidal, Jean-Pierre, Viala, Jacques, Rossi, Jean-Claude
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 21.05.2000
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
ASYMMETRIC-SYNTHESIS
RAT
DOCOSAHEXAENOIC ACID
ALZHEIMERS-DISEASE
ISOPROSTANES
PEROXIDATION IN-VIVO
8-EPI-PROSTAGLANDIN-F2-ALPHA
CYCLIZATION
COREY LACTONE
FREE-RADICALS
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Summary:The first total synthesis of 4( RS)-F 4t-isoprostane methyl ester 1 is described using diacetone- d-glucose as starting material. This new isoprostane (neuroprostane) would be very useful in neurological studies as a potent lipid peroxidation index to obtain an integrated assessment of oxidative stress in the human brain.
ISSN:0040-4039
1873-3581
DOI:10.1016/S0040-4039(00)00508-6