Experimental induction of liver fibrosis in young guinea pigs by combined application of copper sulphate and aflatoxin B 1

Aflatoxin B 1 alone (0.05 mg resp. 0.037 mg/kg/d), copper alone (6.6 mg/kg/d or 200 mg/l drinking water) or a combination of both was administered orally for 6 months to young guinea pigs from the first/second day of life. In the copper group there were no pathomorphological changes. For the aflatox...

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Bibliographic Details
Published inToxicology letters Vol. 92; no. 3; pp. 161 - 172
Main Authors Seffner, Wolfgang, Schiller, Frank, Lippold, Ulrich, Dieter, Hermann H., Hoffmann, Allhard
Format Journal Article
LanguageEnglish
Published Elsevier Ireland Ltd 22.08.1997
Subjects
Aflatoxin B 1
Copper
Guinea pig
Liver injury
Guinea pig
Copper
Aflatoxin B 1
Liver injury
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Summary:Aflatoxin B 1 alone (0.05 mg resp. 0.037 mg/kg/d), copper alone (6.6 mg/kg/d or 200 mg/l drinking water) or a combination of both was administered orally for 6 months to young guinea pigs from the first/second day of life. In the copper group there were no pathomorphological changes. For the aflatoxin B 1 group, liver damage was established. In the combined group, liver injury was more frequent and more severe compared to the aflatoxin B 1 group and biliary copper excretion was diminished compared with the copper group. Histologically, only the livers of this group exhibited degeneration, atrophy and steatosis of liver cells, inflammatory processes and a more or less prominent fibrosis. For childhood cirrhosis (ICC and ICT) a combined etiology—a liver damaging agent plus elevated alimentary copper—is a plausible hypothesis.
ISSN:0378-4274
1879-3169
DOI:10.1016/S0378-4274(97)00052-0