Potent HIV protease inhibitors incorporating high-affinity P 2-ligands and ( R)-(hydroxyethylamino)sulfonamide isostere

Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P 2-ligands and ( R)-(hydroxyethylamino)sulfonamide isostere. Incorporation of structure-based designed, novel, high affinity ligands in the hydroxyet...

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Published inBioorganic & medicinal chemistry letters Vol. 8; no. 6; pp. 687 - 690
Main Authors Ghosh, Arun K, Kincaid, John F, Cho, Wonhwa, Walters, D.Eric, Krishnan, K, Hussain, Khaja Azhar, Koo, Yumee, Cho, Hanna, Rudall, Clare, Holland, Louis, Buthod, Jim
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 17.03.1998
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Summary:Design and synthesis of a series of very potent nonpeptide HIV protease inhibitors are described. The inhibitors are derived from novel high affinity P 2-ligands and ( R)-(hydroxyethylamino)sulfonamide isostere. Incorporation of structure-based designed, novel, high affinity ligands in the hydroxyethylamino-sulfonamide isostere provided very potent series of HIV-1 protease inhibitors.
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(98)00098-5