Regio- and stereoselective ring opening of epoxide with cyanoguanidine dianions, a facile synthesis of the K ATP opener BMS-180448

BMS-180448, (3S,4R)- 2, was prepared in 63% yield via a facile method which involved a new regio- and stereoselective ring opening of epoxide (3S,4S)- 12 with the potassium dianion of cyanoguanidine 11.

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Bibliographic Details
Published inTetrahedron: asymmetry Vol. 9; no. 8; pp. 1337 - 1340
Main Authors Chen, Bang-Chi, Quinlan, Sandra L, Reid, J.Gregory, Jass, Paul A, Robinson, Tonya P, Early, William A, Delaney, Edward J, Humora, Michael J, Madding, Gary D, Venit, John J, Winter, William J
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 24.04.1998
Elsevier
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Chemistry, Physical
Physical Sciences
Science & Technology
ISOLATED RAT HEARTS
REVERSIBLE CARDIOPROTECTIVE AGENT
DOGS
POTASSIUM CHANNEL OPENERS
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Summary:BMS-180448, (3S,4R)- 2, was prepared in 63% yield via a facile method which involved a new regio- and stereoselective ring opening of epoxide (3S,4S)- 12 with the potassium dianion of cyanoguanidine 11.
ISSN:0957-4166
1362-511X
DOI:10.1016/S0957-4166(98)00116-5