Characterization of endothelin A receptors in cerebral and peripheral arteries of the rat

We have characterized and quantified endothelin receptors in rat brain (anterior cerebral) and peripheral (aorta, carotid, and caudal) arteries, with the use of [ 125I]endothelin and quantitative autoradiography. Endothelin binding was saturable, of high affinity, and totally displaced by the select...

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Published inPeptides (New York, N.Y. : 1980) Vol. 16; no. 1; pp. 139 - 144
Main Authors De Oliveira, Ana Maria, Viswanathan, Mohan, Capsoni, Simona, Heemskerk, Frank M.J., Correa, Fernando M.A., Saavedra, Juan M.
Format Journal Article
LanguageEnglish
Published Elsevier Inc 1995
Subjects
Cerebral arteries
Endothelin receptors
Peripheral arteries
Peripheral arteries
Endothelin receptors
Cerebral arteries
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Summary:We have characterized and quantified endothelin receptors in rat brain (anterior cerebral) and peripheral (aorta, carotid, and caudal) arteries, with the use of [ 125I]endothelin and quantitative autoradiography. Endothelin binding was saturable, of high affinity, and totally displaced by the selective endothelin ET A antagonist BQ 123. A single class of ET A receptors is located in the medial layer of peripheral and cerebral arteries, and its quantification by autoradiography allows study of their regulation and function.
ISSN:0196-9781
1873-5169
DOI:10.1016/0196-9781(94)00169-7