A convergent synthesis of Ro24-5913, a novel leukotriene D 4 antagonist

A new and convergent synthesis of the leukotriene D 4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and combinatorial strcture optimization. The synthesis of 6, achieved in 90% yield, is described. The conversion of 6 to 9 has been disclosed previously. A n...

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Published inTetrahedron letters Vol. 37; no. 31; pp. 5445 - 5448
Main Authors Maehr, Hubert, Yang, Roxana
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 29.07.1996
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
WITTIG-HORNER REACTIONS
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Abstract A new and convergent synthesis of the leukotriene D 4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and combinatorial strcture optimization. The synthesis of 6, achieved in 90% yield, is described. The conversion of 6 to 9 has been disclosed previously. A new, convergent synthesis of Ro24-5913, suited for technical production, is described.
AbstractList A new and convergent synthesis of the leukotriene D-4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and combinatorial structure optimization. The synthesis of 6, achieved in 90% yield, is described. The conversion of 6 to 9 has been disclosed previously. Copyright (C) 1996 Elsevier Science Ltd
A new and convergent synthesis of the leukotriene D 4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and combinatorial strcture optimization. The synthesis of 6, achieved in 90% yield, is described. The conversion of 6 to 9 has been disclosed previously. A new, convergent synthesis of Ro24-5913, suited for technical production, is described.
Author Yang, Roxana
Maehr, Hubert
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Snippet A new and convergent synthesis of the leukotriene D 4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and...
A new and convergent synthesis of the leukotriene D-4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and...
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Chemistry, Organic
Physical Sciences
Science & Technology
Title A convergent synthesis of Ro24-5913, a novel leukotriene D 4 antagonist
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