A convergent synthesis of Ro24-5913, a novel leukotriene D 4 antagonist
A new and convergent synthesis of the leukotriene D 4 antagonist Ro24-5913 (9) has been developed that can serve both for technical production and combinatorial strcture optimization. The synthesis of 6, achieved in 90% yield, is described. The conversion of 6 to 9 has been disclosed previously. A n...
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Published in | Tetrahedron letters Vol. 37; no. 31; pp. 5445 - 5448 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
29.07.1996
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | A new and convergent synthesis of the leukotriene D
4 antagonist Ro24-5913
(9) has been developed that can serve both for technical production and combinatorial strcture optimization. The synthesis of
6, achieved in 90% yield, is described. The conversion of
6 to
9 has been disclosed previously.
A new, convergent synthesis of Ro24-5913, suited for technical production, is described. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/0040-4039(96)01190-2 |