Synthesis and characterization of o 6-modified deoxyguanosine-containing oligodeoxyribonucleotides for triple-helix formation

Two new modified deoxyguanosine derivatives linked through their C-6 position to a psoralen and an acridine derivative have been synthesized and incorporated into oligonucleotide chains. Difficulties observed during the purification of oligonucleotides containing a stretch of G and one method used t...

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Bibliographic Details
Published inTetrahedron Vol. 52; no. 6; pp. 2047 - 2064
Main Authors Raynaud, Franqoise, Asseline, Ulysse, Roig, Victoria, Thuong, Nguyen Thanh
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 05.02.1996
Elsevier
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
BASE-PAIRS
ACID
RECOGNITION
PROTECTION
DNA
NUCLEOSIDES
GUANINE
MODEL
OLIGONUCLEOTIDE SYNTHESIS
MOTIF
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Summary:Two new modified deoxyguanosine derivatives linked through their C-6 position to a psoralen and an acridine derivative have been synthesized and incorporated into oligonucleotide chains. Difficulties observed during the purification of oligonucleotides containing a stretch of G and one method used to solve this problem are discussed. Two new modified deoxyguanosine derivatives linked through their C-6 position- to a psoralen and an acridine derivative have been synthesized and incorporated into oligonucleotide chains.
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(95)01043-2