VOSO4 catalyzed highly efficient synthesis of benzimidazoles, benzothiazoles, and quinoxalines

[Display omitted] •Synthesis of benzimidazoles, benzothiazoles, and quinoxalines using VOSO4 as catalyst.•Environmentally benign protocol with mild reaction conditions and high yields.•Wide substrate scope shown by synthesis of structurally diverse benzimidazole derivatives.•Reusability of VOSO4 for...

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Bibliographic Details
Published inTetrahedron letters Vol. 57; no. 36; pp. 4012 - 4016
Main Authors Digwal, Chander Singh, Yadav, Upasana, Sakla, Akash P., Sri Ramya, P.V., Aaghaz, Shams, Kamal, Ahmed
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 07.09.2016
Elsevier
Subjects
Benzimidazoles
Benzothiazoles
Chemistry
Chemistry, Organic
Physical Sciences
Quinoxalines
Science & Technology
VOSO4
Quinoxalines
Benzimidazoles
VOSO4
Benzothiazoles
ROOM-TEMPERATURE
ONE-POT SYNTHESIS
MILD
FACILE SYNTHESIS
VANADIUM
BIOLOGICAL EVALUATION
2-ARYLBENZOTHIAZOLES
CONDENSATION
DERIVATIVES
SCAFFOLD
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Summary:[Display omitted] •Synthesis of benzimidazoles, benzothiazoles, and quinoxalines using VOSO4 as catalyst.•Environmentally benign protocol with mild reaction conditions and high yields.•Wide substrate scope shown by synthesis of structurally diverse benzimidazole derivatives.•Reusability of VOSO4 for at least three times.•The protocol is also useful in gram scale synthesis. Herein, we describe a highly efficient and eco-friendly protocol for the synthesis of benzimidazoles, benzothiazoles, and quinoxalines using VOSO4 as a catalyst in ethanol. Use of nontoxic and recyclable catalyst, clean reaction profile, high yields, scalability, and broad substrate scope are the important practical features of the present protocol.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2016.06.074