Antiinflammatory and antinociceptive effects of the selective histamine H 4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation

The effects of the highly selective histamine H 4 receptor antagonists JNJ7777120 and VUF6002 were investigated on the carrageenan-induced inflammation and thermal hyperalgesia in rats. JNJ7777120 (10 and 30 mg/kg, s.c.) and VUF6002 (10 mg/kg, s.c.) significantly reduced paw edema and hyperalgesia p...

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Published inEuropean journal of pharmacology Vol. 563; no. 1; pp. 240 - 244
Main Authors Coruzzi, Gabriella, Adami, Maristella, Guaita, Elena, de Esch, Iwan J.P., Leurs, Rob
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.06.2007
Subjects
Carrageenan
Histamine H 4 receptor antagonists
JNJ7777120
Paw edema
Thermal hyperalgesia
VUF6002
Paw edema
Carrageenan
JNJ7777120
VUF6002
Thermal hyperalgesia
Histamine H 4 receptor antagonists
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Summary:The effects of the highly selective histamine H 4 receptor antagonists JNJ7777120 and VUF6002 were investigated on the carrageenan-induced inflammation and thermal hyperalgesia in rats. JNJ7777120 (10 and 30 mg/kg, s.c.) and VUF6002 (10 mg/kg, s.c.) significantly reduced paw edema and hyperalgesia provoked by subplantar injection of carrageenan; the effect was evident against the early (2 h) phase of inflammation. An inactive analog of VUF6002, VUF6007 (10 mg/kg, s.c.) slightly aggravated paw edema, while leaving unaltered carrageenan-induced nociception. These findings indicate that histamine H 4 receptors participate in the early phase of acute inflammation induced by carrageenan in rats, influencing both edema and thermal hyperalgesia.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2007.02.026