Synthesis and structure–activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H 1 antagonists

[Display omitted] The synthesis and structure–activity relationships of piperidinylpyrrolopyridines as potent and selective H 1 antagonists are discussed. It was found that the nature of the acid chain bonded to piperidine was a key feature for maintaining both the duration of action in vivo and lac...

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Published inBioorganic & medicinal chemistry letters Vol. 15; no. 4; pp. 1165 - 1167
Main Authors Fonquerna, Silvia, Miralpeix, Montse, Pagès, Lluís, Puig, Carles, Cardús, Arantxa, Antón, Francisca, Vilella, Dolors, Aparici, Mónica, Prieto, José, Warrellow, Graham, Beleta, Jorge, Ryder, Hamish
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 15.02.2005
Subjects
Antihistamine
H 1 antagonists
Piperidinylpyrrolopyridines
Piperidinylpyrrolopyridines
H 1 antagonists
Antihistamine
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Summary:[Display omitted] The synthesis and structure–activity relationships of piperidinylpyrrolopyridines as potent and selective H 1 antagonists are discussed. It was found that the nature of the acid chain bonded to piperidine was a key feature for maintaining both the duration of action in vivo and lack of sedative properties.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2004.12.008