The discovery of novel 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamides as vasopressin V 1A receptor antagonists

The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V 1A receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V 1A antagonists.

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 21; no. 10; pp. 3163 - 3167
Main Authors Napier, Susan, Wishart, Grant, Arbuckle, William, Baker, James, Barn, David, Bingham, Matilda, Brown, Angus, Byford, Alan, Claxton, Chris, Craighead, Mark, Buchanan, Kirsteen, Fielding, Lee, Gibson, Lindsay, Goodwin, Richard, Goutcher, Susan, Irving, Nicholas, MacSweeney, Cliona, Milne, Rachel, Mort, Chris, Presland, Jeremy, Sloan, Hazel, Thomson, Fiona, Turnbull, Zara, Young, Trevor
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 15.05.2011
Subjects
Antagonist
V 1A
Vasopressin
V 1A
Vasopressin
Antagonist
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Summary:The discovery of a novel series of 8-azabicyclo[3.2.1]octan-3-yl)-3-(4-chlorophenyl) propanamide antagonists of the vasopressin V 1A receptor is disclosed. Compounds 47 and 48 were found to be high affinity, selective vasopressin V 1A antagonists.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2011.02.096