멍게껍질 카로테노이드의 색조 화장품 원료의 항산화, 항염증 기능성 평가

• Published in: KSBB Journal Vol. 28; no. 1; pp. 36 - 41
• Main Authors: 티카버나데스, 로마줄리야티, 바터든뭉크자갈, 박시향, 최병대
• Format: Journal Article
• Language: Korean
• Published: 한국생물공학회 2013
• Subjects: 생물공학; DPPH radical; NO; color cosmetics; COX-2; Ascidian tunic carotenoids
• ISSN: 1225-7117; 2288-8268

Carotenoids are fat-soluble red-orange colored pigments found in plants and seafood-derived products, including algae, seaweeds, and fish muscle. In this study, we have demonstrated the molecular mechanism underlying the antioxidants and anti-inflammatory properties of ascidian tunic carotenoids using mouse macrophage cell line (RAW 264.7). Cell viability was not affected by treatment of carotenoids < 10 μg/mL. This treatment also showed negative inhibition on lipopolysaccharide (LPS)-stimulated nitric oxide (NO) and cyclooxygenase-2 (COX-2). The DPPH radical scavenging activity of carotenoids was 47.2% at 100 mg/mL. It also has a potential reducing power (1.025) comparable with ascorbic acid (1.584). The ascidian tunic carotenoids would make a candidate for the commercially interesting biologically active cosmetic pigments.