Dopamine receptor drugs and their applications

• Published in: Handbook of Behavioral Neuroscience Vol. 32; pp. 171 - 186
• Main Authors: Lane, J. Robert, Bonifazi, Alessandro
• Format: Book Chapter
• Language: English
• Published: Elsevier Science & Technology 2025
• Subjects: Allosteric modulators; Antipsychotic; Autism spectrum disorder; Biased agonism; Bipolar disorder; Caged ligands; Dementia; Dopamine; Dopamine agonist; Dopamine receptors; Drug; Drug development; Fluorescent ligands; Major depressive disorder; Mood disorders; Nausea; Parkinson's disease; Pharmacodynamics; Pharmacology; Photoaffinity probes; Photoswitchable ligands; Psychological disorders; Schizophrenia; Substance use disorder; Substance use disorder; Drug; Pharmacodynamics; Photoaffinity probes; Dopamine; Parkinson's disease; Schizophrenia; Bipolar disorder; Pharmacology; Nausea; Drug development; Autism spectrum disorder; Major depressive disorder; Fluorescent ligands; Caged ligands; Allosteric modulators; Psychological disorders; Dopamine agonist; Biased agonism; Mood disorders; Photoswitchable ligands; Antipsychotic; Dopamine receptors; Dementia
• ISBN: 9780443298677; 044329867X
• ISSN: 1569-7339
• DOI: 10.1016/B978-0-443-29867-7.00013-X

This chapter provides a broad overview of the clinical uses and pharmacology of drugs that target the dopamine receptors, including the use of dopamine receptor antagonists as antipsychotics and dopamine agonists for the treatment of the symptoms of Parkinson's disease. It discusses some emerging approaches to develop new dopamine receptor-targeted therapies such as the potential of dopamine D3 receptor antagonists for the treatment of substance use disorders and the potential of dopamine receptor allosteric modulators. Finally, it summarizes the progress being made around the development of new compounds and approaches for use in research with a particular focus on approaches to selectively target the individual receptor subtypes.