The Meerwein–Ponndorf–Verley type reaction in a mixture of supercritical isopropanol/CO 2 in a continuous flow reactor in the presence of alumina

The MPV reaction proceeds in a supercritical fluid in a continuous flow reactor. A system for efficient reduction of aromatic and aliphatic aldehydes to respective alcohols by the Meerwein–Ponndorf–Verley reaction at a contact time of less than 4 min and temperature below 473 K has been developed. T...

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Bibliographic Details
Published inThe Journal of supercritical fluids Vol. 61; pp. 115 - 118
Main Authors Il‘ina, I.V., Sivcev, V.P., Volcho, K.P., Salakhutdinov, N.F., Anikeev, V.I.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 2012
Subjects
Aldehyde
Alumina
Meerwein–Ponndorf–Verley reduction
Myrtenal
Supercritical CO 2
Supercritical isopropanol
Supercritical isopropanol
Supercritical CO 2
Aldehyde
Myrtenal
Meerwein–Ponndorf–Verley reduction
Alumina
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Summary:The MPV reaction proceeds in a supercritical fluid in a continuous flow reactor. A system for efficient reduction of aromatic and aliphatic aldehydes to respective alcohols by the Meerwein–Ponndorf–Verley reaction at a contact time of less than 4 min and temperature below 473 K has been developed. The system comprises a continuous flow reactor, mixed supercritical isopropanol/CO 2 solvent and alumina as a catalyst. Reduction of p-nitobenzealdehyde at 425 K yields p-nitrobenzyl alcohol; at 465 K the main reaction product is p-toluidine. α,β-Unsaturated monoterpenic aldehyde myrtenal was reduced into corresponding α,β-unsaturated alcohol myrtenol. At higher temperatures, reduction of myrtenol to saturated alcohol myrtanol becomes possible.
ISSN:0896-8446
1872-8162
DOI:10.1016/j.supflu.2011.10.004