LKM3 autoantibodies in hepatitis C cirrhosis: a further phenomenon of the HCV-induced autoimmunity

Chronic hepatitis C is frequently associated with laboratory markers—including LKM1 autoantibodies—of autoimmunity. A 62-yr-old woman with hepatitis C cirrhosis presented autoantibodies against liver and kidney microsomal proteins. By further evaluation of autoantibodies using ELISA and immunoblotti...

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Published inThe American journal of gastroenterology Vol. 96; no. 3; pp. 910 - 911
Main Authors Csepregi, Antal, Nemesánszky, Elemér, Luettig, Birgit, Obermayer-Straub, Petra, Manns, Michael Peter
Format Journal Article
LanguageEnglish
Published Elsevier Inc 2001
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Summary:Chronic hepatitis C is frequently associated with laboratory markers—including LKM1 autoantibodies—of autoimmunity. A 62-yr-old woman with hepatitis C cirrhosis presented autoantibodies against liver and kidney microsomal proteins. By further evaluation of autoantibodies using ELISA and immunoblotting LKM1 and LKM3 autoantibodies could be revealed. The target antigen of LKM3 autoantibodies proved to be UGT-1.1 isoenzyme. In the absence of chronic hepatitis D infection or autoimmune hepatitis type 2, this is the first case that reports the occurrence of LKM3 autoantibodies in HCV-induced chronic liver disease.
ISSN:0002-9270
1572-0241
DOI:10.1016/S0002-9270(00)02176-6