Synthèse de métabolites marins 2-aminoimidazoliques: Hyménidine, oroïdine et kéramadine

Through a general synthetic scheme, hymenidin, oroidin and keramadine, all marine 2-aminoimidazole metabolites were prepared. Seven steps from imidazolemethanol provided an improved synthesis of oroidin and the first synthesis of hymenidin and keramadine. Seven steps from imidazolemethanol provided...

Full description

Saved in:
Bibliographic Details
Published inTetrahedron Vol. 53; no. 22; pp. 7605 - 7614
Main Authors Daninos-Zeghal, Sophie, Al Mourabit, Ali, Ahond, Alain, Poupat, Christiane, Potier, Pierre
Format Journal Article
LanguageFrench
Published Elsevier Ltd 02.06.1997
Subjects
hymenidin
keramadine
marine 2-aminoimidazole
oroidin
marine 2-aminoimidazole
keramadine
oroidin
hymenidin
Online AccessGet full text

Cover

More Information
Summary:Through a general synthetic scheme, hymenidin, oroidin and keramadine, all marine 2-aminoimidazole metabolites were prepared. Seven steps from imidazolemethanol provided an improved synthesis of oroidin and the first synthesis of hymenidin and keramadine. Seven steps from imidazolemethanol provided the first synthesis of hymenidin (R 1 = R 2 = H : ΔE), keramadine (R 1 = Me, R 2 = H : ΔZ) and an improved synthesis of oroidin (R 1 = H, R 2 = Br ; ΔE).
ISSN:0040-4020
1464-5416
DOI:10.1016/S0040-4020(97)00452-3