생약 조성물, DTS20의 알코올 분해 및 항염증 효과

• Published in: KSBB Journal Vol. 26; no. 5; pp. 433 - 438
• Main Authors: 윤택준, 조선영, 이수정, 김은영, 신광순, 서형주
• Format: Journal Article
• Language: Korean
• Published: 한국생물공학회 2011
• Subjects: 생물공학; Herbal extracts; alcohol; cytokine; NO; inflammation
• ISSN: 1225-7117; 2288-8268

These studies were conducted to investigate the alcohol degradation effects of the extract of herbal composition (DTS20) containing Viscum album L., Lycium chinense L., Inonotus obliquus and Acanthopanax senticosus H., on the alcohol administered mice. To investigate anti-hangover effect, alcohol and alcohol dehydrogensae (ADH) concentration of blood were measured after oral administration of ethanol. The administration of DTS20 (200-500 mg/kg) had beneficial actions toward alcohol degradation in acute alcohol treated mice model. The oral administration of DTS20 showed decreased gastric mucous membrane damage produced in ethanol treated mice. In addition, intraperitoneal administration of DTS20 showed anti-inflammatory effects in inhibition tests of vascular permeability produced by acetic acid. DTS20 also reduced the concentration of nitric oxide (NO), tumor necrosis factor (TNF)-α in macrophages that were activated by LPS. These results demonstrate that DTS20 possesses potential to stimulate the alcohol degradation and inhibit the inflammatory effects in mice.