Extraction, isolation and structural characterization of two triterpenoid glycosides from the fruits of Ficusbengalensis

• Published in: Carbohydrate research Vol. 510; p. 108444
• Main Authors: Akhtar, Mohammad Sohail, Mir, S.R., Said, Sadri Abdullah, Hossain, Mohammad Amzad, Ali, Mohammad
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.12.2021
• Subjects: Chromatography; Ethanol extract; Ficus - chemistry; Ficus bengalensis; Fruit - chemistry; Glycosides - chemistry; Glycosides - isolation & purification; India; Molecular Conformation; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Spectroscopy; Tritepenoids glycosides derivatives; Triterpenes - chemistry; Triterpenes - isolation & purification; Spectroscopy; Tritepenoids glycosides derivatives; Ficus bengalensis; Ethanol extract; Chromatography; India
• ISSN: 0008-6215; 1873-426X
• DOI: 10.1016/j.carres.2021.108444

Ficus bengalensis (F. bengalensis) is a popular medicinal plant species used extensively in the Ayurveda treatment as hypoglycemic, diuretic, tonic, rheumatism, astringent, and inflammation. The goal of this study is to separate and characterize - compounds from fruits of the selected F. bengalensis. The dried fruits coarse power was defatted with non-polar solvent petroleum ether and then systematically extracted with ethanol by using maceration method for 3 days. The ethanol was evaporated and the prepared extract was separated by several chromatographic methods. After separation, the ethanol extract of F. bengalensis afforded nine compounds including two new triterpenoid glycoside derivatives Compound 1: Bengalensursenyl diglycoside and Compound 2: Ficusbengursenyl diglycoside and other minor known phytochemicals. The chemical structures of these separated phytochemicals were elucidated based on spectroscopic analysis and minor chemical transformations. This paper reports isolation and structure elucidation of compounds 1 and 2. In conclusion, the isolated Compound 1 and Compound 2 could be further investigated for any pharmacological activities. This is the first report in our laboratory on isolation of Compound 1 and Compound 2 from the fruits of F. bengalensis. [Display omitted] •F. bengalensis is a medicinal plant used extensively in the Ayurvedic treatment.•Two new triterpenoids glycosides were isolated from the selected plant for the first time.•To develop separation method for the isolation of new triterpenoids glycosides.•To characterize new glycoside by various chromatographic and spectroscopic methods commercial product.•Further research can be done to identify pharmacological properties of these compounds.