Age-dependent changes in expression of alpha 1-adrenergic receptors in rat myocardium

The expression of alpha 1-adrenergic receptors within ventricular myocardium of rats ranging in age from 21 days of fetal life to 24 months after birth was measured from [ 125I] 2-(β hydroxy phenyl) ethylaminomethyl tetralone binding isotherms. No difference was observed in binding affinity between...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 138; no. 1; pp. 387 - 391
Main Authors Schaffer, William, Williams, R.Sanders
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.07.1986
Subjects
Aging
Analysis of Variance
Animals
Animals, Newborn - metabolism
Female
Myocardium - metabolism
Organ Size
Pregnancy
Rats
Receptors, Adrenergic, alpha - biosynthesis
Weaning
EDTA
DTT
MgCl 2
[ 125I]-HEAT
α 1AR
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Summary:The expression of alpha 1-adrenergic receptors within ventricular myocardium of rats ranging in age from 21 days of fetal life to 24 months after birth was measured from [ 125I] 2-(β hydroxy phenyl) ethylaminomethyl tetralone binding isotherms. No difference was observed in binding affinity between any of the age groups studied. The number of alpha 1-adrenergic receptors was found to be 60–120% higher in membranes from fetal or immature rats up to 25 days of age when compared with adult animals. The increased expression of alpha 1-adrenergic receptors in the developing heart relative to that observed in adult heart is consistent with the hypothesis that alpha 1-adrenergic receptor stimulation may modulate protein synthesis and growth in mammalian myocardium.
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ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(86)90293-7