Development of Chronic Neutrophilic Leukemia

• Published in: Reproductive & developmental biology Vol. 35; no. 4
• Main Authors: Seo, B.B., Daegu University, Gyeongsan, Republic of Korea, Park, H.D., Daegu University, Gyeongsan, Republic of Korea
• Format: Journal Article
• Language: English
• Published: 30.12.2011
• Subjects: Chronic neutrophilic leukemia; GENE; GENES; Human cervical cancer; Protooncogene; Transgenic mice
• ISSN: 1738-2432

The experimental manipulation of protooncogenes and their gene products is a valuable research tool for the study of human neoplasia. In this study, the recently identified human cervical cancer protooncogene (HccR-2) was expressed in transgenic mice under the control of the tetracycline regulatory system. Mice expressing the HccR-2 transgene showed an altered myeloid development characterized by an increased percentage of mature and band-form neutrophils in the peripheral blood, liver and spleen. This phenotype is similar to human chronic neutrophilic leukemia (CNL) in many ways, which is a rare chronic myeloproliferative disorder (CMD) that presents as a sustained leukocytosis of mature neutrophils with a few or no circulating immature granulocytes, an absence of peripheral blood monocytosis, basophilia, or eosinophilia, and an infiltration of neutrophils into the liver, spleen and kidney. Thus, the HccR-2 transgenic mouse model is imperative not only for investigating the biological properties of the HccR-2 protooncogene in vivo, but also for analyzing the mechanisms involved in the progression of CNL.