Enantioseparation of 1,3-oxazolidine derivatives on Chiralcel OD

The enantioseparations of 2,3-diaryl-5-chloro-methyl-1,3-oxazolidines and 2-(4-nitro)-aryl,3-aryl-5-chloro-methyl-1,3-oxazolidines were performed firstly on polysaccharide derivative-based CSP Chiralcel OD. This study showed the advantages of Chiralcel OD for the enantiomeric separation of these oxa...

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Bibliographic Details
Published inZhejiang da xue xue bao. Journal of Zhejiang University. Sciences edition. Li xue ban Vol. 37; no. 1; pp. 67 - 71
Main Authors Cai, Xiao-Jun, Zhang, Da-Tong
Format Journal Article
LanguageChinese
Published Zhejiang University Press 01.01.2010
Subjects
1，3-氧氮杂环戊烷衍生物
Alcohols
chiralcel od
Derivatives
Hexanes
Oxazolidine
Polysaccharides
Recognition
Separation
对映体分离
手性固定相(csp)
高效液相色谱
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ISSN1008-9497
DOI10.3785/j.issn.1008-9497.2010.01.016

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Summary:The enantioseparations of 2,3-diaryl-5-chloro-methyl-1,3-oxazolidines and 2-(4-nitro)-aryl,3-aryl-5-chloro-methyl-1,3-oxazolidines were performed firstly on polysaccharide derivative-based CSP Chiralcel OD. This study showed the advantages of Chiralcel OD for the enantiomeric separation of these oxazolidine derivatives. The influence of variation of polar alcohol modifier concentration and the type in mobile phase hexane on the chiral separation was investigated, and variation of column temperature as well. Then the chiral recognition mechanism was discussed.
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ISSN:1008-9497
DOI:10.3785/j.issn.1008-9497.2010.01.016