FULMINANT EPSTEIN-BARR VIRAL HEPATITIS IN IMMUNOCOMPROMISEDPATIENT WITH CHRONIC LYMPHOCYTIC LEUKAEMIA

Backrgound Fulminant hepatitis with acute hepatic failure caused by Epstein-Barr virus (EBV) reactivation is rare and has high mortality. We report a case of fulminant EBV hepatitis withacute hepatic failure, disseminated intravascular coagulation and multiorgan failure inchronic lymphocytic leukaem...

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Published inZdravniški vestnik (Ljubljana, Slovenia : 1992) Vol. 77; no. SUPPI
Main Authors Grat, Mateja, Jelenko, Tadeja, Vuckovic, Josko
Format Journal Article
LanguageSlovenian
English
Published Ljubljana ZDRAVNISKI VESTNIK - SLOVENIAN MEDICAL JOURNAL 01.04.2008
Slovenian Medical Association
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Summary:Backrgound Fulminant hepatitis with acute hepatic failure caused by Epstein-Barr virus (EBV) reactivation is rare and has high mortality. We report a case of fulminant EBV hepatitis withacute hepatic failure, disseminated intravascular coagulation and multiorgan failure inchronic lymphocytic leukaemia patient in relaps treated with alemtuzumab (monoclonalantiCD52) and standard chemoprophylaxis. After transient neutropenia he becameicteric and had upper abdominal pain. The course was progressive and he died 13 daysafter onset of symptoms. We confirmed serologically and moleculary (EBV-DNA PCR)reactivation of EBV.
ISSN:1318-0347
1581-0024
1581-0224