Visualization Analysis of Research Hotspots and Trends in Treatment of Radioactive Iodine Refractory Differentiated Thyroid Carcinoma

• Published in: Zhongliu fangzhi yanjiu Vol. 52; no. 2; pp. 156 - 164
• Main Authors: Zeng, Xiaoxian, Zhang, Hong
• Format: Journal Article
• Language: Chinese; English
• Published: Tianjin China Anti-Cancer Association 01.02.2025; Magazine House of Cancer Research on Prevention and Treatment
• Subjects: bibliometrics; Cancer; Citation analysis; citespace; Clinical trials; Clustering; Health services; Iodine; Iodine radioisotopes; Kinases; Medical prognosis; Medical research; radioactive iodine refractory differentiated thyroid cancer; Research hot spots; Thyroid; Thyroid cancer; Thyroid carcinoma; treatment; Trends; Tyrosine; vosviewer
• ISSN: 1000-8578
• DOI: 10.3971/j.issn.1000-8578.2025.24.0826

Objective　To explore research hotspots and future development trends in radioactive iodine refractory differentiated thyroid carcinoma (RAIR-DTC) treatment from 2004 to 2024. Methods　Literature on RAIR-DTC treatment published from January 2004 to May 2024 was retrieved from the Web of Science (WOS) database. CiteSpace, VOSviewer, and Microsoft Office Excel were used for visual analysis of publication volume, countries, institutions, authors, keywords, and co-citation networks. Results　A total of 677 articles were included in the analysis. National and institutional co-occurrence analysis revealed that the United States, along with the MD Anderson Cancer Center at the University of Texas, was the most productive and influential in this field. Author and citation co-occurrence analysis highlighted the substantial contributions of Schlumberger M and Brose MS to the field. The exploration of high-frequency keywords and keyword clustering indicated tyrosine kinase inhibitors and disease prognostic factors were current research hotspots. Keyword burst analysis suggested that future research trends would focus on optimizing clinical benefits through reliable data provided from high-quality clinical trials and achieving personalized, precise treatment management. Conclusion　Targeted drugs hold remarkable potential for RAIR-DTC treatment, and emphasizing predictive factors for disease prognosis offers valuable guidance for medical practice.