Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell Carcinoma
Objective To observe the expression of microRNA(miRNA, miR)-181d in esophageal squamous cell carcinoma (ESCC) tissues and to explore its clinical significance. Methods Reverse transcription quantitative real-time PCR(RT-qPCR) was used to detect the miR-181d expression in 37 cases of ESCC tissues and...
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Published in | Zhongliu fangzhi yanjiu Vol. 45; no. 12; pp. 981 - 984 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
Tianjin
China Anti-Cancer Association
01.12.2018
Magazine House of Cancer Research on Prevention and Treatment |
Subjects | |
Online Access | Get full text |
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Summary: | Objective To observe the expression of microRNA(miRNA, miR)-181d in esophageal squamous cell carcinoma (ESCC) tissues and to explore its clinical significance. Methods Reverse transcription quantitative real-time PCR(RT-qPCR) was used to detect the miR-181d expression in 37 cases of ESCC tissues and matched adjacent tissues. The correlations of miR-181d expression with clinicpathological features and clinical prognosis were analyzed. Results miR-181d expression was up-regulated in 89.2%(33/37) of ESCC tissues, compared with the matched adjacent tissues (P<0.01). The expression level of miR-181d was not significantly correlated with gender, age, depth of invasion, lymph node metastasis, histological grade or tumor location(P>0.05), but significantly related to TNM staging (P<0.05). Kaplan-Meier survival analysis showed that the overall survival rate and the disease-free survival rate of the high miR-181d expression group was significantly lower than that of the low miR-181d expression group (P<0.05). Conclusio |
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ISSN: | 1000-8578 1000-8578 |
DOI: | 10.3971/j.issn.1000-8578.2018.18.0716 |