Expression and Clinical Significance of miRNA-181d in Esophageal Squamous Cell Carcinoma

• Published in: Zhongliu fangzhi yanjiu Vol. 45; no. 12; pp. 981 - 984
• Main Authors: Gong, Fenfen, Han, Pengli, Cui, Yuanbo, Cao, Xinguang, Zhao, Ruihua, Zhan, Xiang, Li, Xuemin, Cao, Wei
• Format: Journal Article
• Language: Chinese
• Published: Tianjin China Anti-Cancer Association 01.12.2018; Magazine House of Cancer Research on Prevention and Treatment
• Subjects: Clinical significance; Esophageal cancer; esophageal squamous cell carcinoma; Esophagus; Lymph nodes; Medical prognosis; Metastases; mir-181d; miRNA; Patients; Prognosis; Reverse transcription; Ribonucleic acid; RNA; Squamous cell carcinoma; Survival; Survival analysis; Tissues
• ISSN: 1000-8578; 1000-8578
• DOI: 10.3971/j.issn.1000-8578.2018.18.0716

Objective To observe the expression of microRNA(miRNA, miR)-181d in esophageal squamous cell carcinoma (ESCC) tissues and to explore its clinical significance. Methods Reverse transcription quantitative real-time PCR(RT-qPCR) was used to detect the miR-181d expression in 37 cases of ESCC tissues and matched adjacent tissues. The correlations of miR-181d expression with clinicpathological features and clinical prognosis were analyzed. Results miR-181d expression was up-regulated in 89.2%(33/37) of ESCC tissues, compared with the matched adjacent tissues (P<0.01). The expression level of miR-181d was not significantly correlated with gender, age, depth of invasion, lymph node metastasis, histological grade or tumor location(P>0.05), but significantly related to TNM staging (P<0.05). Kaplan-Meier survival analysis showed that the overall survival rate and the disease-free survival rate of the high miR-181d expression group was significantly lower than that of the low miR-181d expression group (P<0.05). Conclusio