Research Advances on Circular RNA in Malignant Tumors of Digestive System

Circular RNAs (circRNAs) are a class of single-stranded non-coding RNAs that form circular conformations through non-canonical splicing or reverse splicing events. Recently, aberrant expression of circRNA has been observed in several cancers. An increasing number of studies suggested that circRNA is...

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Bibliographic Details
Published inZhongliu fangzhi yanjiu Vol. 52; no. 5; pp. 418 - 422
Main Authors Jiang, Yujuan, Tian, Yantao
Format Journal Article
LanguageChinese
English
Published Tianjin China Anti-Cancer Association 01.05.2025
Magazine House of Cancer Research on Prevention and Treatment
Subjects
biomarker
Cancer
Circular RNA
Digestive system
malignancies of the digestive system
Molecular modelling
prognosis
Tumor suppression
Tumorigenesis
Tumors
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Summary:Circular RNAs (circRNAs) are a class of single-stranded non-coding RNAs that form circular conformations through non-canonical splicing or reverse splicing events. Recently, aberrant expression of circRNA has been observed in several cancers. An increasing number of studies suggested that circRNA is involved in tumor suppression or tumor promotion to varying degrees through diverse molecular mechanisms, highlighting its key role in the occurrence and development of tumors. In this review, we systematically summarize the latest research progress on the function and molecular mechanism of circRNA in malignant tumors of the digestive system. circRNA is expected to be further explored as a target molecule in the treatment of digestive system cancers in the future.
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ISSN:1000-8578
DOI:10.3971/j.issn.1000-8578.2025.24.1330