American cutaneous leishmaniasis : Use of a skin test as a predictor of relapse after treatment
While relapses following clinical cure of American cutaneous leishmaniasis are frequent, no test has been described until now to predict such relapses. A cohort of 318 American cutaneous leishmaniasis patients was followed up for two years after treatment with meglumine antimoniate, during which tim...
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Published in | Bulletin of the World Health Organization Vol. 78; no. 8; pp. 968 - 974 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
Genève
Organisation mondiale de la santé
01.01.2000
World Health Organization The World Health Organization |
Subjects | |
Online Access | Get full text |
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Summary: | While relapses following clinical cure of American cutaneous leishmaniasis are frequent, no test has been described until now to predict such relapses. A cohort of 318 American cutaneous leishmaniasis patients was followed up for two years after treatment with meglumine antimoniate, during which time 32 relapses occurred, 30 in the first year and two in the second (accumulated risk: 10.5%). No association was found between these relapses and the parasite-specific antibody response before and after treatment, or between the relapses and stratification by sociodemographic and clinical characteristics. However when Leishmania was used as antigen, patients with a negative skin test at the time of diagnosis presented a 3.4-fold higher risk (hazard risk = 3.4; 95% confidence interval, 1.7-7.0) of American cutaneous leishmaniasis relapse, compared with patients with a positive response. This result shows that the skin test can be a predictor of American cutaneous leishmaniasis relapse after treatment. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0042-9686 1564-0604 |
DOI: | 10.1590/S0042-96862000000800006 |