Engineering Photothermal Catalytic CO2 Nanoreactor for Osteomyelitis Treatment by In Situ CO Generation

• Published in: Advanced science Vol. 11; no. 25; pp. e2402256 - n/a
• Main Authors: Zhuang, Fan, Jing, Luxia, Xiang, Huijing, Li, Cuixian, Lu, Beilei, Yan, Lixia, Wang, Jingjing, Chen, Yu, Huang, Beijian
• Format: Journal Article
• Language: English
• Published: Weinheim John Wiley & Sons, Inc 01.07.2024; John Wiley and Sons Inc; Wiley
• Subjects: anti‐inflammation; bacterial inhibition; Carbon dioxide; carbon monoxide generation; Catalysis; Efficiency; Fourier transforms; Hyperthermia; Lasers; Light; Morphology; MXenes; Nanoparticles; Photocatalysis; photothermal CO2 catalysis; Physiology; Polyethylene glycol; Spectrum analysis; Transmission electron microscopy
• ISSN: 2198-3844; 2198-3844
• DOI: 10.1002/advs.202402256

Photocatalytic carbon dioxide (CO2) reduction is an effective method for in vivo carbon monoxide (CO) generation for antibacterial use. However, the available strategies mainly focus on utilizing visible‐light‐responsive photocatalysts to achieve CO generation. The limited penetration capability of visible light hinders CO generation in deep‐seated tissues. Herein, a photothermal CO2 catalyst (abbreviated as NNBCs) to achieve an efficient hyperthermic effect and in situ CO generation is rationally developed, to simultaneously suppress bacterial proliferation and relieve inflammatory responses. The NNBCs are modified with a special polyethylene glycol and further embellished by bicarbonate (BC) decoration via ferric ion‐mediated coordination. Upon exposure to 1064 nm laser irradiation, the NNBCs facilitated efficient photothermal conversion and in situ CO generation through photothermal CO2 catalysis. Specifically, the photothermal effect accelerated the decomposition of BC to produce CO2 for photothermal catalytic CO production. Benefiting from the hyperthermic effect and in situ CO production, in vivo assessments using an osteomyelitis model confirmed that NNBCs can simultaneously inhibit bacterial proliferation and attenuate the photothermal effect‐associated pro‐inflammatory response. This study represents the first attempt to develop high‐performance photothermal CO2 nanocatalysts to achieve in situ CO generation for the concurrent inhibition of bacterial growth and attenuation of inflammatory responses. The distinct photothermal CO2 nanocatalysts, NNBCs, is engineered to generate hyperthermia and in situ CO, tackling bacterial proliferation and inflammation simultaneously. Under 1064 nm laser irradiation, these NNBCs produce heat that facilitates bicarbonate decomposition to CO2. Evidence from the osteomyelitis models underscore their ability to stifle bacterial growth and soothe inflammation, marking a pioneering approach in antibacterial and anti‐inflammatory nanomedicine.