Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids
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| Published in | Protein & cell Vol. 11; no. 10; pp. 771 - 775 |
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| Main Authors | , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Beijing
Higher Education Press
01.10.2020
Oxford University Press |
| Subjects | |
| Online Access | Get full text |
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| Author | Ni, Chao Gao, Ran Wang, Yuyan Yang, Li Wei, Jinsong Liang, Junbo Zhao, Bing Xu, Wei Lin, Xinhua Lv, Ting Xie, Youhua Zhang, Qisheng Liang, Jianqing Zhang, Rong Wang, Xiaoyue Yuan, Zhenghong |
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| Author_xml | – sequence: 1 givenname: Bing surname: Zhao fullname: Zhao, Bing email: bingzhao@fudan.edu.cn (B. Zhao) organization: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China – sequence: 2 givenname: Chao surname: Ni fullname: Ni, Chao organization: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China – sequence: 3 givenname: Ran surname: Gao fullname: Gao, Ran organization: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China – sequence: 4 givenname: Yuyan surname: Wang fullname: Wang, Yuyan organization: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China – sequence: 5 givenname: Li surname: Yang fullname: Yang, Li organization: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China – sequence: 6 givenname: Jinsong surname: Wei fullname: Wei, Jinsong organization: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China – sequence: 7 givenname: Ting surname: Lv fullname: Lv, Ting organization: Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China – sequence: 8 givenname: Jianqing surname: Liang fullname: Liang, Jianqing organization: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China – sequence: 9 givenname: Qisheng surname: Zhang fullname: Zhang, Qisheng organization: Sino Organoid Lifesciences Ltd., Shanghai 201900, China – sequence: 10 givenname: Wei surname: Xu fullname: Xu, Wei organization: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China – sequence: 11 givenname: Youhua surname: Xie fullname: Xie, Youhua organization: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China – sequence: 12 givenname: Xiaoyue surname: Wang fullname: Wang, Xiaoyue organization: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China – sequence: 13 givenname: Zhenghong surname: Yuan fullname: Yuan, Zhenghong organization: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China – sequence: 14 givenname: Junbo surname: Liang fullname: Liang, Junbo email: liangjunbo@ibms.pumc.edu.cn (J. Liang) organization: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China – sequence: 15 givenname: Rong surname: Zhang fullname: Zhang, Rong email: rong_zhang@fudan.edu.cn (R. Zhang) organization: Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai 200032, China – sequence: 16 givenname: Xinhua surname: Lin fullname: Lin, Xinhua email: xlin@fudan.edu.cn (X. Lin) organization: State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai 200438, China |
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| References | ChenNZhouMDongXQuJGongFHanYQiuYWangJLiuYWeiYEpidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive studyLancet20203955075131:CAS:528:DC%2BB3cXhvFOmsb8%3D10.1016/S0140-6736(20)30211-7 Fan Z, Chen L, Li J, Tian C, Zhang Y, Huang S, Liu Z, Cheng J (2020) Clinical features of COVID-19 related liver damage. medRxiv Qi F, Qian S, Zhang S, Zhang Z (2020) Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses. bioRxiv Chai X, Hu L, Zhang Y, Han W, Lu Z, Ke A, Zhou J, Shi G, Fang N, Fan J, et al (2020) Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. bioRxiv Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, et al (2020) Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell HuchMGehartHvan BoxtelRHamerKBlokzijlFVerstegenMMEllisEvan WenumMFuchsSAde LigtJLong-term culture of genome-stable bipotent stem cells from adult human liverCell20151602993121:CAS:528:DC%2BC2MXnslGrsA%3D%3D10.1016/j.cell.2014.11.050 Wan, Y., Shang, J., Graham, R., Baric, R.S., and Li, F. (2020). Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol 94. DuttaDCleversHOrganoid culture systems to study host-pathogen interactionsCurr Opin Immunol20174815221:CAS:528:DC%2BC2sXht1WhsbjM10.1016/j.coi.2017.07.012 HuangCWangYLiXRenLZhaoJHuYZhangLFanGXuJGuXClinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaLancet20203954975061:CAS:528:DC%2BB3cXhs1Kqu7c%3D10.1016/S0140-6736(20)30183-5 Zhang H, Kang Z, Gong H, Xu D, Wang J, Li Z, Cui X, Xiao J, Meng T, Zhou W, et al (2020) The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. bioRxiv ZhuNZhangDWangWLiXYangBSongJZhaoXHuangBShiWLuRA novel coronavirus from patients with pneumonia in China, 2019N Engl J Med20203827277331:CAS:528:DC%2BB3cXjslGmsrc%3D10.1056/NEJMoa2001017 KuhnJHLiWChoeHFarzanMAngiotensin-converting enzyme 2: a functional receptor for SARS coronavirusCell Mol Life Sci200461273827431:CAS:528:DC%2BD2cXhtFGit7rE10.1007/s00018-004-4242-5 Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., and Zuo, W. (2020). Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov. bioRxiv. WuFZhaoSYuBChenYMWangWSongZGHuYTaoZWTianJHPeiYYA new coronavirus associated with human respiratory disease in ChinaNature20205792652691:CAS:528:DC%2BB3cXksFKlsLc%3D10.1038/s41586-020-2008-3 32606457 - Nature. 2020 Jul;583(7814):15-16 |
| References_xml | – reference: WuFZhaoSYuBChenYMWangWSongZGHuYTaoZWTianJHPeiYYA new coronavirus associated with human respiratory disease in ChinaNature20205792652691:CAS:528:DC%2BB3cXksFKlsLc%3D10.1038/s41586-020-2008-3 – reference: Zhao, Y., Zhao, Z., Wang, Y., Zhou, Y., Ma, Y., and Zuo, W. (2020). Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCov. bioRxiv. – reference: HuangCWangYLiXRenLZhaoJHuYZhangLFanGXuJGuXClinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaLancet20203954975061:CAS:528:DC%2BB3cXhs1Kqu7c%3D10.1016/S0140-6736(20)30183-5 – reference: Zhang H, Kang Z, Gong H, Xu D, Wang J, Li Z, Cui X, Xiao J, Meng T, Zhou W, et al (2020) The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes. bioRxiv – reference: Fan Z, Chen L, Li J, Tian C, Zhang Y, Huang S, Liu Z, Cheng J (2020) Clinical features of COVID-19 related liver damage. medRxiv – reference: Chai X, Hu L, Zhang Y, Han W, Lu Z, Ke A, Zhou J, Shi G, Fang N, Fan J, et al (2020) Specific ACE2 expression in cholangiocytes may cause liver damage after 2019-nCoV infection. bioRxiv – reference: Qi F, Qian S, Zhang S, Zhang Z (2020) Single cell RNA sequencing of 13 human tissues identify cell types and receptors of human coronaviruses. bioRxiv – reference: Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, Liu S, Zhao P, Liu H, Zhu L, et al (2020) Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med – reference: Hoffmann M, Kleine-Weber H, Schroeder S, Kruger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell – reference: ZhuNZhangDWangWLiXYangBSongJZhaoXHuangBShiWLuRA novel coronavirus from patients with pneumonia in China, 2019N Engl J Med20203827277331:CAS:528:DC%2BB3cXjslGmsrc%3D10.1056/NEJMoa2001017 – reference: KuhnJHLiWChoeHFarzanMAngiotensin-converting enzyme 2: a functional receptor for SARS coronavirusCell Mol Life Sci200461273827431:CAS:528:DC%2BD2cXhtFGit7rE10.1007/s00018-004-4242-5 – reference: ChenNZhouMDongXQuJGongFHanYQiuYWangJLiuYWeiYEpidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive studyLancet20203955075131:CAS:528:DC%2BB3cXhvFOmsb8%3D10.1016/S0140-6736(20)30211-7 – reference: HuchMGehartHvan BoxtelRHamerKBlokzijlFVerstegenMMEllisEvan WenumMFuchsSAde LigtJLong-term culture of genome-stable bipotent stem cells from adult human liverCell20151602993121:CAS:528:DC%2BC2MXnslGrsA%3D%3D10.1016/j.cell.2014.11.050 – reference: DuttaDCleversHOrganoid culture systems to study host-pathogen interactionsCurr Opin Immunol20174815221:CAS:528:DC%2BC2sXht1WhsbjM10.1016/j.coi.2017.07.012 – reference: Wan, Y., Shang, J., Graham, R., Baric, R.S., and Li, F. (2020). Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol 94. – reference: 32606457 - Nature. 2020 Jul;583(7814):15-16 |
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| SubjectTerms | Angiotensin-Converting Enzyme 2 Betacoronavirus - isolation & purification Betacoronavirus - pathogenicity Bile Acids and Salts - metabolism Bile Ducts, Intrahepatic - pathology Bile Ducts, Intrahepatic - virology Biochemistry Biomedical and Life Sciences Cell Biology Cell Culture Techniques Coronavirus Infections - complications Coronavirus Infections - pathology COVID-19 Cytokine Release Syndrome - etiology Cytokine Release Syndrome - physiopathology Cytopathogenic Effect, Viral Developmental Biology Epithelial Cells - enzymology Epithelial Cells - pathology Epithelial Cells - virology Human Genetics Humans Hyperbilirubinemia - etiology Letter Life Sciences Liver - pathology Organoids - pathology Organoids - virology Pandemics Peptidyl-Dipeptidase A - analysis Pneumonia, Viral - complications Pneumonia, Viral - pathology Protein Science Receptors, Virus - analysis SARS-CoV-2 Serine Endopeptidases - analysis Stem Cells Viral Load |
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| Title | Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids |
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